Biomimetic chitosan with biocomposite nanomaterials for bone tissue repair and regeneration

• Se-Kwon Kim,
• Sesha Subramanian Murugan,
• Pandurang Appana Dalavi,
• Sebanti Gupta,
• Sukumaran Anil,
• Gi Hun Seong and
• Jayachandran Venkatesan

Beilstein J. Nanotechnol. 2022, 13, 1051–1067, doi:10.3762/bjnano.13.92

• wettability and protein adsorption which can facilitate osteogenesis [129]. Biomaterials such as chitosan and its composites containing bioactive metals draw much attention in tissue engineering and regenerative applications. Chitosan-based composites are now being studied in wound healing, bone and cartilage

• regeneration, and other applications. Furthermore, chitosan-containing polymer composites are being extensively explored for drug delivery in targeted tumour treatment and nucleic acid delivery in genetic engineering applications. More research is required to optimise chitosan composites utilised in scaffolds

Micro- and nanotechnology in biomedical engineering for cartilage tissue regeneration in osteoarthritis

• Zahra Nabizadeh,
• Mahmoud Nasrollahzadeh,
• Hamed Daemi,
• Mohamadreza Baghaban Eslaminejad,
• Ali Akbar Shabani,
• Mehdi Dadashpour,
• Majid Mirmohammadkhani and
• Davood Nasrabadi

Beilstein J. Nanotechnol. 2022, 13, 363–389, doi:10.3762/bjnano.13.31

• /nanoscale topographical cues, microspheres, nanoparticles, nanofibers, and nanotubes. Keywords: biological cues; cartilage regeneration; micro/nanotopographical cues; nanotechnology; osteoarthritis; regenerative medicine; Review 1 Introduction Osteoarthritis (OA) is a widespread degenerative disease of

• system in the context of cartilage regeneration meets the specific challenges, which limit the local delivery of bioactive molecules. In vitro chondrogenesis relies on the gradual addition of growth factors to the culture medium, which is impractical in vivo. The development of a series of scaffolds

• chondrogenesis of MSCs and cartilage regeneration, which should be performed over a period of several days or weeks. However, a few of the proposed methods achieved the prolonged sustained release of bioactive molecules. For example, low molecular weight polyethyleneimine precoated poly(lactide-co-glycolide